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LIONBERRY & The Heartland Elderberry Collaborative AgriCluster 

LIONBERRY & The Heartland Elderberry Collaborative AgriCluster 

LIONBERRY & The Heartland Elderberry Collaborative AgriCluster 

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Kansas Agriculture Day at the State Capitol in Topeka

March 18, 2025

Featuring Kansas-made products to highlight the state’s $88 billion industry, with Governor Laura Kelly designating March as Agriculture Month. 

To register for this event please visit the following URL: https://www.agriculture.ks.gov/about-us/kansas-agriculture-celebrations →

 

Date And Time

03-18-2026 to
03-18-2026
 

Location

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BUSINESS SECRETS WEEKLY

Lionberry 's Weekly Delusion and Re-illusion Update.

Lionberry’s Weekly Delusion and Re-Illusion Update

THE BOTTOM LINE — FOR THOSE WHO DON’T READ THE WHOLE THING:

You did not gain this weight on purpose. And you are not lazy. Your biology is working against you and the pharmaceutical industry figured that out before your doctor did.

Maybe you are on Ozempic. Maybe you are on Wegovy or Rybelsus — same drug, semaglutide, different name on the box. Maybe you switched to tirzepatide — Mounjaro for diabetes, Zepbound for weight loss — because it works better and your doctor said so and they are right, it does. Maybe you are watching retatrutide come through clinical trials right now, the triple agonist hitting GLP-1, GIP, and glucagon all at once, and you are waiting for it because nothing has been enough yet.

Or maybe you went off one of these drugs and the weight came back and you are furious. Or you never wanted a needle in the first place. Or you are watching the bill every month and doing math you do not like.

Or you are just tired. Tired of the afternoon crash. The brain fog. The blood sugar swings. The feeling that your body is running against you no matter what you do.

You are not alone. And you are not out of options.

There is a berry that has been growing in the dirt of the American Midwest for centuries. Farmers knew it. Grandmothers knew it. Scientists are now catching up. Washington State University published a clinical trial showing that elderberry juice — real juice, not a capsule, not a powder, not a gummy — reduced blood glucose by 24%, dropped insulin levels by 9%, and increased fat oxidation by 27%. In one week.

The mechanism supports your body’s own GLP-1 response — the same hormone every drug on that list was designed to mimic. Not because someone engineered elderberry to do that. Because that is what the plant does.

The prebiotic power of elderberry is not new information. It has been known — in farming communities, in food science, in microbiome research — for years. Then the peer-reviewed, statistically significant, USDA-funded clinical trial came out of Washington State University and made it official. The internet, in its infinite wisdom, kept scrolling past a peer-reviewed USDA-funded clinical trial to watch someone unbox supplements on TikTok.

What the category still does not have is a functional beverage actually built around this science — fresh-pressed, farm-grown, anthocyanins intact. Not a supplement. A drink.

The research never went away. The conversation is just finally catching up.

Berberine is getting the “nature’s Ozempic” headline. Berberine is in a capsule. Elderberry is a fresh-pressed fruit with intact anthocyanins — grown in the dirt of the American Midwest — and nobody is talking about it.

That last part matters. A lot. We’ll get there.

The GLP-1 Conversation Got Hijacked. Twice.

First, pharmaceuticals hijacked it. Semaglutide showed up, the world lost its mind, and suddenly every conversation about metabolic health ran through a needle.

Then berberine hijacked it. “Nature’s Ozempic,” they called it. Fair enough — berberine has real research behind it and genuine metabolic effects. But berberine comes in a capsule. It is an extracted, concentrated supplement. It is not food. It is not a drink. It is not something you pour into your day.

Elderberry has not been sitting quietly. The science has been building for years. The mainstream conversation just has not caught up yet.

That is starting to change.

1. WHAT THE STUDY ACTUALLY FOUND

In January 2025, researchers at Washington State University’s Elson S. Floyd College of Medicine published the results of a randomized, placebo-controlled crossover trial in the journal Nutrients. Lead researcher Patrick Solverson, assistant professor of Nutrition and Exercise Physiology at WSU, designed the trial specifically to test 100% elderberry juice against a flavor and sugar-matched placebo — meaning participants couldn’t tell which one they were drinking, and the sugar content was controlled so the results couldn’t be explained away by sweetness alone.

Eighteen overweight adults. One week of elderberry juice. Here is what happened:

Blood glucose dropped 24%. After a high-carbohydrate meal challenge, participants who had been drinking elderberry juice processed sugar significantly better than when they drank the placebo. Not a little better. 24% better.

Insulin levels dropped 9%. Lower insulin means the body is managing glucose more efficiently. Insulin reduction precedes fat loss. This is not a trivial number.

Fat oxidation increased 27%. Participants burned more fat — both at rest and during exercise — when consuming elderberry juice. The body shifted toward burning fat as a fuel source instead of storing it.

Gut bacteria changed meaningfully. Beneficial bacterial species increased. Harmful ones decreased. The microbiome shifted toward a profile associated with better metabolic health in one week.

Solverson’s own words: “Elderberry is an underappreciated berry, commercially and nutritionally. We’re now starting to recognize its value for human health, and the results are very exciting.”

That is a researcher who has spent years on this data saying out loud that elderberry has been underestimated.

He is correct.

2. THE MECHANISM — WHY THIS IS NOT A COINCIDENCE

This is the part the headlines skip. They print the numbers and move on. The numbers are impressive, but the mechanism is the story.

Here is what is actually happening inside your body when you drink elderberry juice with intact anthocyanins:

Elderberry is extraordinarily dense in a specific class of compounds called cyanidin-based anthocyanins. These are the deep purple pigments that give the berry its color. They are bioactive. They are not decoration.

When those anthocyanins reach your gut, they become prebiotic fuel. They feed specific strains of beneficial bacteria — including Bifidobacterium and Akkermansia — that produce short-chain fatty acids as a byproduct of fermentation.

Those short-chain fatty acids — butyrate, propionate, acetate — do several things. They reduce inflammation in fat tissue. They improve insulin sensitivity. And critically: they directly stimulate L-cells in the lining of your gut to secrete GLP-1.

GLP-1. Glucagon-like peptide-1. The hormone semaglutide was engineered to mimic.

Your gut makes it naturally. Elderberry anthocyanins tell it to make more.

This is not a supplement claim. This is documented biochemistry published in a peer-reviewed journal funded by the United States Department of Agriculture.

The plant supports your body’s natural GLP-1 response. From the inside out. Through the microbiome. Through food.

3. THE PROCESSING PROBLEM NOBODY TALKS ABOUT

Here is where most elderberry products fail — and why the science in this study does not automatically apply to everything with “elderberry” on the label.

The anthocyanins are the active compounds. They are what drives the GLP-1 mechanism. They are what produced the 24% blood glucose reduction in the WSU trial.

Anthocyanins are heat-sensitive.

Most elderberry products on the market — syrups, gummies, capsules, powders — are processed at high heat for extended periods. It is cheaper. It is faster. It kills pathogens. It also destroys a significant portion of the anthocyanins in the process. You are left with a product that tastes like elderberry, looks like elderberry, and has almost none of the bioactive compounds that make elderberry worth anything metabolically.

The elderberry category has an overcooked problem. The plant gets blamed for the processing failure. People try elderberry syrup, feel nothing metabolic, and write off the whole category.

The fix is not complicated. Fresh-pressed elderberry with pH dropped immediately using tart cherry — not heat, not extended cooking — and processed at 164°F for 45 seconds. Enough to be safe. Not enough to torch the anthocyanins. That is the standard any elderberry product making metabolic claims should be held to.

What was in the WSU study was juice. Not a powder. Not a gummy. Not a capsule. Not a syrup. Fresh-pressed juice with the compounds intact — because that is the only form that produced these results.

4. THE GLP-1 OFF-RAMP — METABOLIC SUPPORT IN THE POST-APPETITE ERA

WSU is not done with this research.

With additional funding from the USDA’s National Institute of Food and Agriculture, the research team is now exploring a specific follow-on question: can elderberry help people maintain weight loss and metabolic stability after discontinuing GLP-1 medications?

This is the question millions of people are about to need answered.

GLP-1 drugs work. They also cost $1,000 a month, require a weekly injection, and when people stop taking them — the weight comes back. The metabolic reset doesn’t hold without support. The gut microbiome that was doing work under the drug needs something to keep feeding it.

Elderberry’s anthocyanins feed the bacteria that produce the SCFAs that trigger endogenous GLP-1 production. That is a natural, food-based mechanism for supporting the same pathway the drug was doing pharmacologically.

This is the white space in the GLP-1 conversation right now. Three audiences, all underserved: people coming off GLP-1 medications who need metabolic support to maintain their results. People who do not want to start them and are looking for a food-based path. And people who simply want daily metabolic support — something that feeds the biology instead of overriding it.

That is the post-appetite economy. And food brands that understand it are going to matter.

5. WHY BERBERINE IS NOT THE ANSWER TO THIS QUESTION

Berberine deserves its moment. It has real research. It works through a different mechanism — AMPK activation — and has genuine effects on blood sugar and metabolism.

But berberine is not food. It is a concentrated plant extract in a capsule because the dose required for efficacy is not achievable through diet. It does not feed your gut microbiome. It does not stimulate GLP-1 through the SCFA pathway. It works around the food system, not through it.

The “nature’s Ozempic” framing was always the wrong lens. The question is not which plant mimics a drug. The question is which food supports the biology the drug was designed to target.

Elderberry’s GLP-1 effect is mechanistically specific. It runs through the microbiome. It is amplified by the prebiotic fiber in the berry. It works the way food is supposed to work — by feeding the systems your body already has.

That is a different category. That is a better story. And it has been sitting in a peer-reviewed journal for over a year waiting for someone to tell it.

THE BOTTOM LINE — ONE MORE TIME

Elderberry has a randomized controlled trial showing 24% blood glucose reduction, 9% insulin drop, and 27% fat oxidation increase in one week. The mechanism supports the body’s natural GLP-1 response via gut microbiome stimulation. The research is funded by the USDA. The lead researcher at WSU is now studying whether elderberry can support people coming off GLP-1 medications.

The post-appetite economy is here. By 2030, 35% of American households will have someone on a GLP-1 drug. What happens alongside those drugs — and after them — is the conversation the food industry has not had yet.

Elderberry just handed it a place to start.

RESEARCH CITATIONS

Because we didn’t make this up.

[1] Solverson et al. (2024). A One-Week Elderberry Juice Intervention Augments the Fecal Microbiota and Suggests Improvement in Glucose Tolerance and Fat Oxidation in a Randomized Controlled Trial. Nutrients, Vol. 16, No. 20, Article 3555. DOI: 10.3390/nu16203555. https://www.mdpi.com/2072-6643/16/20/3555

[2] WSU Press Release (January 2025). Elderberry Juice Shows Benefits for Weight Management, Metabolic Health. Elson S. Floyd College of Medicine. https://medicine.wsu.edu/news/2025/01/09/elderberry-juice-benefits/

[3] Tremaroli V, Bäckhed F. (2012). Functional interactions between the gut microbiota and host metabolism. Nature, 489, 242–249. DOI: 10.1038/nature11552

[4] Tolhurst G et al. (2012). Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2. Diabetes, 61(2), 364–371. DOI: 10.2337/db11-1019

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